pentobarbital increases levels of vortioxetine by expanding metabolism. Modify Therapy/Watch Closely. Contemplate escalating the vortioxetine dose when coadministered with strong CYP inducers for >14 times; not to exceed 3 moments initial vortioxetine dose.pentobarbital will lower the level or impact of ibuprofen by impacting hepatic enzyme CYP2C9/